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FDA Embraces Personalized Medicine

Food and Drug Administration Acting Director Frank Torti announced Monday in a podcast the creation of a new position in the Office of Chief Scientist: the Senior Genomics Advisor. Dr. Liz Mansfield, a scientist who has worked on scientific policy [...]

WEISS'S NOTEBOOK

Speedy FDA Process Gets Observers’ Goats

A Food and Drug Administration advisory panel has deemed a drug from a genetically engineered animal to be safe and effective even though the agency has not yet decided what the rules for such approvals should be.

Pinker On Genes and the Brain

Personalized genetic testing can tell us about our physical traits, but what can it tell us about psychology? In this Sunday’s New York Times Magazine, Harvard professor Steven Pinker combines a narrative of personal genetic discovery with some insight into [...]

Argumentum ad Mitochondrium

A Turkish opposition leader has accused President Abdullah Gül of secret Armenian ancestry as the reason for his failure to reject a campaign to apologize for Turkey’s genocidal war against Armenians in the early 20th century. Republican People’s Party Deputy Canan Aritman demands that the president submit to a DNA test. But one would think that any Turkish political leader seeking to distance Turks from a holocaust would want to avoid racial biology as an explanation for anything.

How Many Copies Is Enough?

gene sequence with ellipsesCopy number variation refers to the fact that the number of copies of a gene, or deletions from sequences within a person’s DNA, along with the placement of those copies or deletions, contributes to his or her inherited characteristics. That is, the copies or deletions are themselves genetic information. Using sequencing methods, researchers can identify the variation in sequence patterns across a population. Spotting those variations is one challenge, but associating them with observable characteristics is another matter altogether.

WEISS'S NOTEBOOK

The Revolution Will Be Personalized

It will be an uphill battle to justify some of the upfront costs of the personalized medicine revolution, given the technical, political, and educational hurdles that stand between where we are and where we want to get: to a place with better care that costs less.

BIOTECHNOLOGY

An Emerging Consensus

The international community is developing policies that support embryonic stem cell research and embryo screening for medical purposes, but oppose human reproductive cloning, embryo screening for non-medical purposes, and genetic “enhancement.”

GENETICS

Spitomics

The first stop on the road to a healthcare revolution: saliva-collection parties. But as the nascent direct-to-consumer genetic testing industry grows, what can consumers really expect to learn from these services?

The $5000 Complete Genome and the Coming Genetic Microsofts

DBN array from Complete  GenomicsEarlier this week, Complete Genomics announced that it will offer complete human genome sequencing for the low, low price of $5000. But as the blog Genetic Future points out, in this industry, profits will to flow to companies that can offer the best interpretation of genetic information, not just the fastest and cheapest sequencing.

Medicare-Funded Gene Test Could Propel Personalized Medicine Research

About two million patients take warfarin, or coumadin, each year to prevent blood clotting during medical procedures. The Centers for Medicare and Medicaid Services of the Department of Health and Human Services invited public commentary on whether Medicare should fund genetic tests to determine a patient’s warfarin response. This possible change in policy might save thousands of lives and highlights the need for a more comprehensive approach to the field of personalized medicine.

Genetic Privacy in Practice

DNA under magnifying glassAt the beginning of the month, NIH pulled pooled GWAS data from its website and began encouraging other institutions to follow suit, because a team of scientists have figured out just how to identify a single person’s DNA from a sample of hundreds.

STEM CELLS

Ethically Challenged

An expert panel at Stanford University has determined that nearly one quarter of the colonies of human embryonic stem cells that the Bush administration had approved as ethically derived and eligible for study with federal funds do not meet Stanford’s ethics standards and should no longer be available to researchers there.

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