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	<title>Comments on: Reprogramming Cells With Protein Power</title>
	<atom:link href="http://scienceprogress.org/2009/04/reprogramming-cells/feed/" rel="self" type="application/rss+xml" />
	<link>http://scienceprogress.org/2009/04/reprogramming-cells/</link>
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		<title>By: Dr. Carlos Rodríguez</title>
		<link>http://scienceprogress.org/2009/04/reprogramming-cells/comment-page-1/#comment-6164</link>
		<dc:creator>Dr. Carlos Rodríguez</dc:creator>
		<pubDate>Sat, 03 Oct 2009 22:09:51 +0000</pubDate>
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		<description>I wonder if introducing a foreing protein can activate the inmune system</description>
		<content:encoded><![CDATA[<p>I wonder if introducing a foreing protein can activate the inmune system</p>
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		<title>By: A retired biochemist</title>
		<link>http://scienceprogress.org/2009/04/reprogramming-cells/comment-page-1/#comment-4934</link>
		<dc:creator>A retired biochemist</dc:creator>
		<pubDate>Mon, 27 Apr 2009 21:43:17 +0000</pubDate>
		<guid isPermaLink="false">http://www.scienceprogress.org/?p=2767#comment-4934</guid>
		<description>valproic acid &quot;wipes DNA clean of its endogenous, or original, binding proteins&quot;

Using the drug valproic acid &quot;may alter DNA&quot;

NO and NO.

While valproate has been shown conclusively to be a teratogen there is little evidence that this comes from any mutagenic activity.

Aside from its effects on GABA/ion channels, valproate is thought to enhance cell reprogramming through its ability to inhibit histone deacetylases.

Histones, the spool-like proteins that package DNA in the nucleus, can undergo the reversible chemical modification of acetylation.

While acetylation probably makes histone-DNA interactions &quot;looser&quot; and more changeable it does not strip the DNA clean.

Dr Loring undoubtedly knows all of this, and thus needs to edit her staff&#039;s work more closely.</description>
		<content:encoded><![CDATA[<p>valproic acid &#8220;wipes DNA clean of its endogenous, or original, binding proteins&#8221;</p>
<p>Using the drug valproic acid &#8220;may alter DNA&#8221;</p>
<p>NO and NO.</p>
<p>While valproate has been shown conclusively to be a teratogen there is little evidence that this comes from any mutagenic activity.</p>
<p>Aside from its effects on GABA/ion channels, valproate is thought to enhance cell reprogramming through its ability to inhibit histone deacetylases.</p>
<p>Histones, the spool-like proteins that package DNA in the nucleus, can undergo the reversible chemical modification of acetylation.</p>
<p>While acetylation probably makes histone-DNA interactions &#8220;looser&#8221; and more changeable it does not strip the DNA clean.</p>
<p>Dr Loring undoubtedly knows all of this, and thus needs to edit her staff&#8217;s work more closely.</p>
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